Observations on Biotin
نویسندگان
چکیده
منابع مشابه
Effect of Supplemental Biotin on Performance of
Biotin is a B-complex vitamin that is essential for cattle. However, for several decades very little research was published on the effects of biotin in cattle. This lack of interest was probably caused by the inability to produce clinical biotin deficiencies in functioning ruminants and by the consensus that adequate biotin was in normal feedstuffs or was synthesized by bacteria in the rumen an...
متن کاملEffects of Biotin Deficiency on Biotinylated Proteins and Biotin-Related Genes in the Rat Brain.
Biotin is a water-soluble vitamin that functions as a cofactor for biotin-dependent carboxylases. The biochemical and physiological roles of biotin in brain regions have not yet been investigated sufficiently in vivo. Thus, in order to clarify the function of biotin in the brain, we herein examined biotin contents, biotinylated protein expression (e.g. holocarboxylases), and biotin-related gene...
متن کاملFurther studies on the biotin coenzyme.
During the past several years much progress has been made in the understanding of the enzymatic functions of biotin. Although the mode of action of biotin remains to be elucidated, it is quite clear that this vitamin is involved in the oxalacetate decarboxylase system (Lardy et al., 1947; Lichstein and Umbreit, 1947; Shive and Rogers, 1947; Ochoa et al., 1947; Wessman and Werkman, 1950), the re...
متن کاملBiotin Monograph
Introduction Biotin is a water-soluble B vitamin that is an essential cofactor for four carboxylase enzymes, each of which catalyzes an essential step in intermediary metabolism. Because humans and other mammals cannot synthesize biotin, it must be derived from dietary sources and de novo synthesis by intestinal bacteria. Biotin was originally recognized when rats fed protein derived from egg w...
متن کاملHomogeneous Enzyme-linked Competitive Binding Assay for Biotin Based on the Avidin-biotin Interaction
A homogeneous enzyme-linked competitive-binding assay for biotin with glucose-6-phosphate dehydrogenase (GGPDH), is described. This assay is based on the interaction between a GGPDH/biotin conjugate with avidin, a natural binder for biotin. In the absence of biotin in the assay mixture, this interaction results in 100% inhibition of the enzyme conjugate. In the presence of biotin, the enzymatic...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1951
ISSN: 0022-202X
DOI: 10.1038/jid.1951.17